The prime minister is expected to urge trade unions to modernise and grasp opportunities he believes are opening up because of globalisation.
Tony Blair is also set tell unions not to be afraid of a changing world.
Activists from more than 20 unions will also hear Mr Blair spell out challenges he believes trade unions face.
At the same conference, TUC General Secretary Brendan Barber will urge the government to stand up to employers over pensions.
Mr Barber is set to warn the government that its relationship with unions would be "hugely damaged" if it failed to do so.
At Saturday's conference, organised by union think tank Unions 21, Mr Blair is also likely to hint that unions should not be afraid of engaging more with society.
It is a message the prime minister has delivered before, and which has not always gone down well with trade unionists.
'Crucial test'
Mr Barber will tell the conference the government should adopt measures recommended by the Pensions Commission, including compulsory contributions by employers.
"To me, this is an absolutely crucial test for the prime minister and the government," he will say.
"We have been disappointed too often in the past, when I think the government has given in to crude employer lobbying."
Mr Barber will also tell the audience of trade union activists and politicians that if the commission's main conclusions are not adopted, the government will miss an "historic" opportunity to give women a fair pensions deal.
(BBC)
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